KEGG   Rattus norvegicus (rat): 58819
Entry
58819             CDS       T01003                                 
Symbol
Txnrd1
Name
(RefSeq) thioredoxin reductase 1, cytoplasmic isoform 1
  KO
K22182  thioredoxin reductase (NADPH) [EC:1.8.1.9]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00450  Selenocompound metabolism
rno05200  Pathways in cancer
rno05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    58819 (Txnrd1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    58819 (Txnrd1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    58819 (Txnrd1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.9  thioredoxin-disulfide reductase
     58819 (Txnrd1)
SSDB
Motif
Pfam: Pyr_redox_2 Pyr_redox_dim Pyr_redox Pyr_redox_3 FAD_binding_2 HI0933_like AlaDh_PNT_C Thi4 FAD_oxidored GIDA NAD_binding_8 DAO Lycopene_cycl
Other DBs
NCBI-GeneID: 58819
NCBI-ProteinID: NP_001338910
RGD: 61959
Ensembl: ENSRNOG00000009088
Position
7:complement(22717620..22802553)
AA seq 499 aa
MNDSKDAPKSYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCV
NVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVAL
REKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISS
DDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHM
EEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTI
GLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGG
STVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNK
CYAKVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFT
TLSVTKRSGGDILQSGCUG
NT seq 1500 nt   +upstreamnt  +downstreamnt
atgaatgactctaaagatgcccctaagtcctatgacttcgacctgatcatcattggagga
ggctcgggaggcctggcggcagctaaggaggcagccaaatttgacaagaaggtgatggtc
ttggacttcgtcacaccaactcctctcggaacgagatggggtctcgggggaacgtgtgtg
aacgtgggctgcatacctaaaaaactgatgcaccaggcggctctgttaggacaagctctg
aaagactcacgcaactatggctggaaactcgaggacacagttaagcatgactgggagaaa
atgacagaatctgtgcagaatcatatcggctcgctgaactggggctaccgagtagctctc
cgggagaagaaggttgtctatgagaatgcttacgggaaattcattggtcctcacaaaatt
atggcaacaaataacaaaggtaaagaaaaagtttactcagcagagcggttcctcattgcc
accggtgaaaggccgcgctacctgggcatccctggagacaaagagtactgcatcagcagt
gacgatcttttctccttgccttactgcccggggaagaccctagtggttggcgcgtcctat
gtcgccttggaatgtgcaggattcctggctggtatcggcctcgacgtcactgtaatggtg
cggtccattctccttagaggatttgaccaggacatggccaacaaaattggtgaacacatg
gaagagcatggtatcaagtttatcaggcagttcgtgccgacgaaaattgaacagattgaa
gcagggacaccaggccgactcaaggtgaccgctaagtccacaaacagtgaggagaccata
gaagacgaatttaacacagtgttgcttgcagtaggaagagattcttgtacaagaactatt
ggcttagagaccgtgggcgtgaagatcaatgaaaagaccgggaagatacctgtcacggat
gaggagcagaccaatgtgccttacatctacgccattggtgacattctggaggggaagctg
gagctgacccccgtggccatccaggcggggagattgctggctcagaggctgtatggcggc
tccactgtcaaatgtgactatgacaatgtcccaacgactgtgtttactcctttggagtat
ggctgctgtggcctctctgaagaaaaagctgtagagaaatttggggaagaaaatattgaa
gtttaccacagtttcttctggccattggaatggacagttccatcccgggataacaacaaa
tgttatgcaaaagtcgtctgtaaccttaaagacaacgaacgtgtcgtgggcttccacgta
ctgggtccaaatgctggagaggtgacgcagggctttgcagccgcactcaagtgcgggctg
accaagcagcagctggacagcaccattggcatccacccggtctgtgcagagatatttaca
acgctgtcggtgactaagcgttctgggggagacatcctccagtctggctgctgaggttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (28)   
   RefSeq(nuc) (4)   
   GenBank (12)   
   EMBL (12)   
Protein domain (13)   
   Pfam (13)   
All databases (68)   

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